中文名 | TIE-2/VEGFR-2 kinase-IN-1 |
英文名 | TIE-2/VEGFR-2 kinase-IN-1 |
英文别名 | Kinase IN-1 6-(4-METHOXYPHENYL)FURO[2,3-D]PYRIMIDIN-4-AMINE 6-(4-methoxy-phenyl)-furo[2,3-d]pyrimidin-4-ylamine |
CAS | 453590-24-4 |
化学式 | C13H11N3O2 |
分子量 | 241.25 |
存储条件 | -20°C,密封,干燥 |
体外研究 | Angiopoieten 1 is a ligand for the endotheiium-specific receptor tyrosine kinase, TIE-2 is a novel angiogenic factor.Inhibition of TIE-2 is expected to serve to disrupt remodeling and maturation of new vasculature initiated by angiogenesis thereby disrupting the angiogenic process. Inhibition at the kinase domain binding site of VEGFR-2 would block phosphorylation of tyrosine residues and serve to disrupt initiation of angiogenesis. |
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